What is FH?1,2
Familial hypercholesterolemia (FH) is a genetic disorder of the lipoprotein metabolism, which is characterized by significantly elevated low-density lipoprotein-cholesterol LDL-C
The Dutch Lipid Clinical Network (DLCN) is a scoring criteria for diagnosing FH.
It has been recommended by the European Atherosclerosis Society (EAS) to identify people with FH.1
Family history of
premature CVD in their
family members
Their own CVD history
Untreated lipid levels
Physical signs
Patients with HoFH or compound HeFH present with distinctive and severe clinical manifestations very early in life (< 10 years old). On the other hand, patients with HeFH are, by and large, asymptomatic in childhood and adolescence and typically diagnosed by screening methods. 6
FH is an inherited condition, but it is manageable when diagnosed early. If the patient has not shown any clinical symptoms, prevention of primary manifestation is prioritized. Otherwise, treating and mitigating further complications should be the focus.1